2022 Quality Summit ePosters (Non-CE) - CathPCI Registry-18. Effect of Left Ventricular End-Diastolic Pressure on Response and Safety of Post-Percutaneous Coronary Intervention High-Dose Hydration to Prevent Acute Kidney Injury: A Single-Center 4-Year Experience

18. Effect of Left Ventricular End-Diastolic Pressure on Response and Safety of Post-Percutaneous Coronary Intervention High-Dose Hydration to Prevent Acute Kidney Injury: A Single-Center 4-Year Experience

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Pdf Summary

The study examined the role of left ventricular end-diastolic pressure (LVEDP) in guiding hydration to prevent acute kidney injury (AKI) in patients undergoing percutaneous coronary intervention (PCI). It was hypothesized that patients undergoing PCI may have a peri-procedural volume deficit, making them more prone to AKI. The exact dose of hydration to reduce the risk of AKI remains undetermined. <br /><br />A previous pilot study found that patients who received a universal high-dose hydration protocol (HDHP) had a significant drop in post-PCI serum creatinine levels compared to the control group. However, the role of LVEDP in guiding post-procedural hydration dosing is not well-established.<br /><br />The study aimed to assess the variation in response to and the safety of the HDHP based on patients' procedural LVEDP. Data from patients undergoing PCI were analyzed to determine if universal HDHP is tolerated regardless of LVEDP. The study suggests that, in most cases, universal HDHP is well-tolerated regardless of LVEDP. <br /><br />Overall, the study highlights the importance of post-procedural hydration in reducing the risk of AKI in patients undergoing PCI. It suggests that a policy of universal high-dose hydration for all patients post-PCI, regardless of their risk, can safely address the peri-procedural volume deficit. However, more research is needed to determine the optimal dose of hydration and the precise role of LVEDP in guiding hydration therapy.

Keywords

left ventricular end-diastolic pressure

LVEDP

hydration

acute kidney injury

AKI

percutaneous coronary intervention

PCI

volume deficit

high-dose hydration protocol

post-procedural hydration