Medication Review: DOACs vs Warfarin Non-CE-Lesson 3

Video Transcription

Video Summary

Lesson 3 of this learning activity is focused on comparing DOACs (direct oral anticoagulants) with Warfarin as oral anticoagulant options. Warfarin requires extensive monitoring of INR levels and dietary restrictions, while DOACs require no routine lab monitoring and have more flexibility in food choices. Warfarin has a more complex dosing regimen and may require changes to the weekly dose, leading to potential noncompliance. However, Warfarin is still commonly prescribed due to its wide range of indications. It is the only anticoagulant approved for patients with mechanical heart valves and antiphospholipid syndrome. Warfarin also has a well-established reversal protocol. Factors such as onset of action, half-life, patient adherence, comorbid conditions, drug-drug interactions, and contraindications in pregnancy should be considered when choosing an oral anticoagulant. The preferred anticoagulant may vary based on these factors, and switching between anticoagulants should be done carefully.

Keywords

DOACs

Warfarin

oral anticoagulants

INR levels

dietary restrictions